Scopolamine Treated Mice
Scopolamine is a tropane alkaloid drug with competitive antagonism at muscarinic acetylcholine receptors (mAChR). Systemic application of scopolamine disrupts performance on several reference memory tasks, such as object discrimination, radial arm maze, water maze and fear conditioning . The scopolamine induced cognitive impairment is reversible by cholinesterase inhibitors amongst others.Therefore this model can be used to mimic cognitive dysfunction observed in dementia and AD and is a useful initial screening method to identify therapeutic candidates.
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